Figure 5 | Scientific Reports

Figure 5

From: Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships

Figure 5The alternative text for this image may have been generated using AI.

Synthesis of 6–7. Reagents and conditions: (a) N2,N6-Bis(benzyloxycarbonyl)-L-lysine, BOP, Et3N, THF, 3.5 h, rt, 64%; (b) 1 atm H2(g), Pd/C 10%, THF, 6 h, rt, quantitative; (c) Boc-Arg(Boc)2-OH, BOP, Et3N, THF, 2 h, rt, 95%; (d) TFA, CH2Cl2, 2 h, rt, 79%.

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