Figure 3 | Scientific Reports

Figure 3

From: A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice

Figure 3The alternative text for this image may have been generated using AI.

C23 improves lung histological architecture after CLP. At 20 h after CLP, (A) the lungs of sham-operated mice showed normal histological architecture, while the lungs of septic mice treated with (B) vehicle or (C) C23 displayed alveolar wall thickening with predominantly interstitial neutrophil accumulation. HE staining; representative photomicrographs, 200×. (D) The lung histological injury score, graded by an investigator blinded to the interventions, was significantly higher in mice adjuvantly treated with vehicle than in mice treated with C23. Data are presented as means ± SE. Number of animals in each group: sham n = 5, vehicle n = 12, C23 n = 11. *p < 0.05 vs. sham, #p < 0.05 vs. vehicle; one-way ANOVA followed by Student-Newman-Keuls test.

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