Table 2 Effects of C23 on systemic and tissue levels of proinflammatory cytokines at 20 h after CLP.
Cytokine | Sham | Vehicle | p-value | C23 | p-value | p-value |
|---|---|---|---|---|---|---|
Mean ± SE | Mean ± SE | vs. sham | Median ± SE | vs. sham | vs. veh | |
Serum (pg/ml) | ||||||
IL-6 | 34.8 ± 16.7 | 33,364.40 ± 6,312.60 | 0.001 | 18,341.10 ± 3.8 | 0.018 | 0.059 |
TNF-α | 3.4 ± 0.5 | 416.5 ± 60.7 | <0.001 | 180.1 ± 16.9 | 0.032 | <0.001 |
IL-1β | 7.8 ± 2 | 53.5 ± 10.8 | 0.005 | 28.7 ± 2.2 | 0.127 | 0.028 |
Lung (pg/mg) | ||||||
IL-6 | 187 ± 8.7 | 2,369.20 ± 481.2 | <0.001 | 1,024.80 ± 240.5 | 0.044 | 0.005 |
TNF-α | 67.5±1.7 | 185.6 ± 11 | <0.001 | 133.5 ± 4.3 | <0.001 | <0.001 |
IL-1β | 179.9 ± 4 | 454.3 ± 20.8 | <0.001 | 346 ± 14.7 | <0.001 | <0.001 |
Kidney (pg/mg) | ||||||
IL-6 | 724.7 ± 20.3 | 2,075.30 ± 285.3 | <0.001 | 1,220.50 ± 128.6 | 0.038 | 0.003 |
TNF-α | 301.5 ± 11.2 | 676 ± 31.1 | <0.001 | 599.2 ± 35.4 | <0.001 | 0.087 |
IL-1β | 934 ± 8.4 | 2,383.40 ± 93.3 | <0.001 | 2,167.80 ± 62.7 | <0.001 | 0.051 |
