Figure 1
From: Exhaustive search for epistatic effects on the human methylome
Power analysis exhaustive search for epistatic effects. In (a) we adjusted alpha to reach genome-wide and methylome-wide Bonferroni correction (discovery phase, p = 6.8 × 10−18). In (b) we adjusted alpha to reach a per-CpG Bonferroni correction threshold (replication phase, p = 3.8 × 10−6). The legends depict the variance that can be explained (in percentage) for different effect sizes (r min = 0.03, 0.1%; r max = 0.55, 30%). The vertical gray bars correspond to a sample size of N = 533 (discovery sample) and N = 319 (replication sample).
