Table 2 Main results exhaustive search for epistatic effects.
From: Exhaustive search for epistatic effects on the human methylome
N unique CpGs | Average N hits per CpG | Max N hits per CpG | N hits in total | Both SNPs in cis | One SNP in cis and in trans | Both SNPs in trans | |
|---|---|---|---|---|---|---|---|
Before replication | 13,112 | 657 | 46,314 | 8,608,567 | 0.03% | 0.20% | 99.78% |
After replication | 1,477 | 3 | 131 | 4,816 | 43.60% | 10.36% | 46.03% |
+Permutation and sign-test | 802 | 3 | 49 | 2,262 | 90.45% | 3.98% | 5.57% |
Per-CpG model approach | 174 | 1 | 5 | 239 | 88.28% | 4.18% | 7.53% |
+Exclusion of LD-block associated effects | 47 | 1 | 3 | 55 | 63.64% | 18.18% | 18.18% |
