Figure 7

Micro-CT images of explanted critical sized calvarial defect after 12 weeks of implantation with HCCS-PDA with rMSC aggregates, HCCS with rMSC aggregates, and autograft (A). Red dotted circle: defect site (red dotted circle: 8 mm in diameter). Bone volume of the defect site including HCCS-PDA/HCCS and newly formed bone was quantified (n = 4, *p < 0.05) (B).