Table 1 Illustration of the common and cancer-specific pathways and the miRNA-mRNA interactions involved in KIRC and KIRP.
From: Dynamic and Modularized MicroRNA Regulation and Its Implication in Human Cancers
Enriched Pathways | Interactions in KIRC | Interactions in KIRP | |
|---|---|---|---|
Common | PI3K-ATK Signaling Pathway | MYC-miR-17-5p; TSC1-miR-320a; PPP2R1A-miR-106a-5p/ -941; TP53-miR-454-3p; JAK1-miR-15b-5p; JAK2-miR-195-5p; PTEN-miR-181b-5p | MYC-miR-17-5p/ -320a/ -423-5p/ -744-5p/ let-7b-5p; TSC1-miR-320a; PPP2R1A-miR-17-5p/ -222-3p/ -92a-3p; TP53-miR-222-3p/ -324-5p; CCND1-miR-15a-5p/ -193b-3p/ -196a-5p/ -92a-3p; FGFR2-miR-186-5p; MAP2K1-miR-93-3p; NRAS-miR−877-3p; STK11-miR-17-5p |
Cell Cycle | CREBBP-let-7e-5p/miR-1301-5p; MYC-miR-17-5p; TP53-miR-454-3p; EP300-miR-30c-5p; ATM-miR-3144-3p/ -92a-3p; CDKN2A-miR-455-3p; STAG2-miR-193b-3p; ABL1-let-7b-5p | CREBBP-let-7e-5p/ miR-1301-5p/ -935; EP300-let-7b-5p/ -193b-3p/ -92a-3p; MYC-miR-17-5p/ -320a/ -423-5p/ -744-5p/let-7b-5p; TP53-miR-222-3p/ -324-5p; CDKN2A-miR-320a; CCND1-miR-15a-5p/ -193b-3p/ -196a-5p/ -92a-3p | |
Thyroid Hormone Signaling Pathway | CREBBP-let-7e-5p/miR-1301-5p; MYC-miR-17-5p; NCOA3-miR-20a-5p; NOTCH2-miR-744-5p/ -27b-3p/ -25-3p/ -92a-3p; TP53-miR-454-3p; EP300-miR-30c-5p; CTNNB1-miR-744-5p | CREBBP-let-7e-5p/miR-1301-5p/ -935; MYC-miR-17-5p/ -320a/ -423-5p/ -744-5p/ let-7b-5p; NCOA3-miR-20a-5p; NOTCH2-miR-744-5p/ -106a-5p/ -130b-5p/ let-7c-5p; TP53-miR-222-3p/ -324-5p; EP300-let-7b-5p/ -193b-3p/ -92a-3p; CCND1-miR-15a-5p/ -193b-3p/ -196a-5p/ -92a-3p; NRAS-miR-877-3p; MAP2K1-miR-93-3p; MED12-miR-454-3p | |
KIRC-Specific | Herpes Simplex Infection | CREBBP-let-7e-5p/miR-1301-5p; TP53-miR-454-3p; EP300-miR-30c-5p; JAK1-miR-15b-5p; JAK2-miR-195-5p; PTEN-miR−181b-5p; PTPN11-miR-130b-3p/ −183-5p/ −193b-3p | |
Transcriptional Misregulation | MYC-miR-17-5p; TP53-miR-454-3p; ATM-miR-3144-3p/ −92a-3p; CEBPA-miR-744-5p; H3F3A-miR-100-5p; MEN1-miR-17-5p | ||
Jak-STAT Signaling Pathway | CREBBP-let-7e-5p/ miR-1301-5p; MYC-miR-17-5p; EP300-miR-30c-5p; JAK1-miR-15b-5p; JAK2-miR-195-5p; PTEN-miR-181b-5p; PTPN11-miR-130b-5p/ -183-5p/ -193b-3p | ||
KIRP-Specific | MAPK Signaling Pathway | MYC-miR-17-5p/ -320a/ -423-5p/ -744-5p / let-7b-5p; TP53-miR-222-3p/ -324-5p; BRAF-miR-191-5p / -744-5p; FGFR2-miR-186-5p; MAP3K1-let-7g-5p/ miR-423-3p; MAP2K1-miR-93-3p; NRAS-miR-877-3p | |
Rap1 Signaling Pathway | GNAS-miR-331-3p; BRAF-miR-191-5p/ -744-5p; FGFR2-miR-186-5p; MAP2K1-miR-93-3p; NRAS-miR-877-3p | ||
Central Carbon Metabolism | MYC-miR-17-5p/ -320a/ -423-5p/ -744-5p/ let-7b-5p; TP53-miR-222-3p/ -324-5p; FGFR2-miR-186-5p; MAP2K1-miR-93-3p; NRAS-miR-877-3p |
