Table 3 Multivariate Cox Regression of prognostic factors in NSCLC.
Variables | Number of patients | |||
|---|---|---|---|---|
OS | LCSS | |||
HR(95% CI) | P | HR(95% CI) | P | |
Age | <0.001 | 0.001 | ||
<60 y | 1 | 1 | ||
≥60 y | 1.511(1.305–1.750) | 1.345(1.130–1.601) | ||
Sex | <0.001 | <0.001 | ||
Male | 1 | 1 | ||
Female | 0.662(0.601–0.729) | 0.688(0.611–0.775) | ||
Race | 0.05 | 0.048 | ||
White | 1 | 1 | ||
Nonwhite | 0.872(0.760–1.000) | 0.841(0.707–0.999) | ||
Histology | <0.001 | 0.224 | ||
Adenocarcinoma | 1 | 1 | ||
Nonadenocarcinoma | 1.199(1.089–1.320) | 1.077(0.956–1.213) | ||
Tumor size | 0.043 | 0.001 | ||
3–4 cm | 1 | 1 | ||
4–5 cm | 1.105(1.003–1.218) | 1.217(1.080–1.372) | ||
Differential degree | ||||
Well or Moderate | 1 | <0.001 | 1 | <0.001 |
Poor or Undifferentiated | 1.289(1.170–1.420) | <0.001 | 1.427(1.264–1.610) | <0.001 |
Unknown | 0.836(0.665–1.051) | 0.125 | 0.928(0.704–1.223) | 0.594 |
Regional nodes examined | ||||
None | 1 | 0.528 | 1 | 0.343 |
1 to 30 | 0.772(0.533–1.117) | 0.17 | 0.653(0.421–1.013) | 0.057 |
31 to 60 | 0.880(0.543–1.428) | 0.605 | 0.702(0.386–1.277) | 0.246 |
61 to 90 | 0.562(0.076–4.130) | 0.571 | 0 | 0.888 |
Other | 0.847(0.570–1.257) | 0.409 | 0.746(0.465–1.196) | 0.224 |
Scope of regional LN surgery | ||||
None | 1 | 0.163 | 1 | 0.182 |
1 to 3 | 0.850(0.566–1.277) | 0.434 | 1.002(0.616–1.630) | 0.994 |
> = 4 | 0.774(0.520–1.152) | 0.207 | 0.879(0.545–1.417) | 0.596 |
Other | 0.669(0.431–1.038) | 0.073 | 0 0.704(0.412–1.203) | 0.2 |
Surgery modality | ||||
Wedge resection | 1 | <0.001 | 1 | <0.001 |
Segmental resection | 1.015(0.768–1.340) | 0.918 | 0.882(0.622–1.252) | 0.483 |
Lobectomy | 0.768(0.642–0.919) | 0.004 | 0 0.694(0.558–0.862) | 0.001 |
Pneumonectomy | 1.042(0.776–1.399) | 0.784 | 1.053(0.740–1.499) | 0.775 |
Other | 1.428(1.045–1.951) | 0.025 | 1.393(0.960–2.021) | 0.081 |
