Figure 4 | Scientific Reports

Figure 4

From: Cell-surface major vault protein promotes cancer progression through harboring mesenchymal and intermediate circulating tumor cells in hepatocellular carcinomas

Figure 4

The biological function of csMVP is mediated through the control of mTOR, FAK, ERK and Akt signaling. (a) Western blot analysis of MVP, Akt1/2/3 and ERK1/2 in Huh7 cells treated with rIgG or α-MVP. The phosphorylation of Akt1/2/3 and ERK1/2 was also examined in Huh7 cells treated with rIgG or α-MVP. The signal intensities of Western blots were measured quantitatively using the Image J software, and GAPDH was used as a loading control. (b) Western blot analysis of MVP, S6, FAK in Huh7 cells treated with rIgG or α-MVP. The phosphorylation of S6 and FAK was also examined in Huh7 cells treated with rIgG or α-MVP. β-actin was used as a loading control.

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