Figure 7 | Scientific Reports

Figure 7

From: Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis

Figure 7

An illustration suggesting OSM or IL-6 presence in the lung acts as stimuli to further potentiate fibrotic disease development. Bleomycin exposure initiate epithelial injury, leading to the recruitment of immune cells and pro-fibrotic alternative macrophage polarization. Our data suggest that both gp130 cytokines, OSM or IL-6, have the capacity to enhance the fibrotic response to bleomycin, associated with an increased number of alternatively activated macrophages. We show further that IL-6 have the capacity to act directly on pulmonary macrophages as opposed to OSM, as macrophages do not express the OSM receptor.

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