Figure 6
Histogram showing gold particle density for P2X3 in the astrocytic soma (a,b), large (a,c), fine (a,d), terminal (a,e) astrocytic processes, and axon terminals (f) of the sham and CCI-ION rats. In the sham rats, the density of P2X3 is much higher in the fine and terminal astrocytic processes than in the soma and large astrocytic processes (a). The density of P2X3 (total and associated with the plasma membrane) in the fine and terminal astrocytic processes is significantly higher in CCI-ION than in sham rats (d,e), whereas it is low in soma and large astrocytic processes, and is not significantly different between sham and CCI-ION rats (b,c). The density of P2X3 in axon terminals is significantly higher in CCI-ION than in sham rats. Asterisks indicate significant difference between CCI-ION rats and sham rats (unpaired Student’s t-test; *P < 0.05, **P < 0.01, ***P < 0.001). N = 3 animals per group.
