Figure 6
From: RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages
Representation of signaling cascade regulated by ADAR1 in MDM. ADAR1 modulates the recognition of non-self dsRNA in the cytoplasm; consequently, sensing of non-self dsRNA induces expression of RNA sensors, RIG-I and MDA5, through downstream effectors, MAVS and TBK1, and transcription factors IRF3 and IRF7. Leading to induction of an innate immune response characterized by increase expression of type I IFN and ISG and subsequent over production of cytokines and chemokines able to block HIV-1.
