Figure 7
From: Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III
FESEM images of WT and AAV2-Clrn1-UTR injected KO-TgAC1 mice at P100. All images are from the sub-apical region of the cochlea. WT shows normal OHC bundles (A,B). The injected KO-TgAC1 mouse with 65 dB SPL ABR threshold (to click stimulus) showed more spread-out or disorderly hair bundles in general (C) compared to the injected KO-TgAC1 mouse with 40 dB SPL ABR threshold (to click stimulus) (E). However, in the closeups of the OHC bundles, some short stereocilia are missing in both examples (D,F *). Scale bars (A,C,E) = 10 µm; (B,D,F) = 1 µm.
