Figure 10
From: Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3
Expression of ACCN1-3 and Kaplan-Meier survival analyses. All 329 glioma patients with available mRNA data from the Rembrandt database were used to determine the relative expression of ACCN1-3 in human glioma and normal brain and the association of ACCN2 and ACCN3 expression with overall survival. (a) Boxplots illustrating the expression level of ACCN1 (ASIC2, top; p < 0.01, Student´s t-test), ACCN2 (ASIC1, centre), and ACCN3 (ASIC3, bottom) in GBM, oligodendroglioma, astrocytoma, and non-tumour control, respectively. Whiskers display the minimal and maximal values, respectively. ***P < 0.001. (b,c) Kaplan-Meier survival curves of pooled glioma samples (including GBM, oligodendroglioma, and astrocytoma) with high or low expression (above or below the median) of ACCN2 or ACCN3. (b) Survival depending on high or low ACCN2 expression (P < 0.001, log-rank test). (c) Survival depending on high or low ACCN3 expression (P = 0.003, log-rank test).
