Figure 3
From: Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3
Toxin sensitivity of ASICs in R54 cells. (a) Top, representative whole cell current traces for type 1 and type 2 currents, activated by pH 6, before, during and after application of 30 nM PcTx1; conditioning pH was 7.4. Bottom, summary of peak currents before, during and after PcTx1. n = 4. (b) As in (a) but with conditioning pH 7.3. n = 5. (c) As in (a) but with 500 nM APETx2. n = 5. *P < 0.05; **P < 0.01.
