Table 2 Functional properties of ASIC currents in R54 and R8 cells compared to properties of recombinant human ASICs in heterologous expression systems.

From: Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3

  

Ï„des (sec at pH 5)

pH50 act.

R54

Type 1

1.4 ± 0.1 (15)

6.4 ± 0.1 (8)

Type 2

1.2 ± 0.1 (14)

6.5 ± 0.1 (7)

R8

Type 2

1.2 ± 0.1 (17)

6.7 ± 0.1 (10)

hASIC1a

 

1.1–3.01,2

6.45–6.551,2

hASIC1b

 

0.553

5.93

hASIC3

 

0.5 ± 0.04 (7) at pH 6

6.554

  1. Values for R54 and R8 cells are mean ± SEM; the number n of measurements is indicated in parentheses. Values for recombinant ASICs are from the literature; references are indicated in superscripts and are as follows: 1(Gunthorpe, 2001), 2(Sherwood, 2008), 3(Hoagland, 2010), 4(Delaunay, 2012). n.d., not determined. τdes for hASIC3 was determined in HeLa cells with a recombinant clone.
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