Figure 3 | Scientific Reports

Figure 3

From: In vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide

Figure 3

In vivo photoacoustic imaging. (A) Ultrasound (US) and (B) MR (T1-weighted, contrast-enhanced) images show structure of human xenograft breast (BT474) tumor (arrows) in nude mouse. Photoacoustic images collected at 1 hour post-injection of (C) KSP*-IR800 and (D) PPS*-IR800 show tumor expression of ErbB2 (arrows). (E) The T/B ratios from BT474 and MDA-MB-231 tumors over time show peak peptide uptake at 1 hour and return to baseline levels at ~24 hours post-injection. (F) T/B ratios from n = 11 tumors in n = 8 mice are shown at 1 hour post-injection. We fit an ANOVA model with terms for 4 means, and found 2.0-fold greater signal with KSP*-IR800 in BT474 versus MDA-MB-231 tumors. The difference of differences was significant, P = 1.9 × 10−3.

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