Table 1 Screening of compounds 3a-o against variety of α-glycosidases.
Compounds (structures) | Compound #s | IC50s in μMa | ||
|---|---|---|---|---|
α-glucosidase (yeast) | α-fucosidase (bovine kidney) | α-mannosidase (jack bean) | ||
| 3a | 5.93 | >50 | >50 |
| 3b | 5.88 | >50 | >50 |
| 3c | 4.50 | >50 | >50 |
| 3d | 5.68 | >50 | >50 |
| 3e | 4.93 | 34.43 | >50 |
| 3 f | 5.95 | 48.08 | >50 |
| 3 g | 5.15 | >50 | 49.41 |
| 3 h | 5.17 | >50 | >50 |
| 3i | 5.93 | >50 | 23.82 |
| 3j | 5.89 | >50 | 44.78 |
| 3k | 5.81 | >50 | 36.21 |
| 3 l | 5.20 | >50 | >50 |
| 3 m | 10.15 | >50 | >50 |
| 3n | 10.13 | >50 | >50 |
| 3o | 6.93 | >50 | >50 |
Acarbose | — | 9.95 | ||
