Table 1 Clinical parameters for the classification of dry eye disease and control patients at each proteomic analysis.

From: Proteomic analysis of human lacrimal and tear fluid in dry eye disease

Specific step of proteomics analysis

Group

No. of Patients (female, n)

Age (years)

Schirmer test I (mm)

Tear breakup time (s)

Protein concentration (μg/μl)

Global profiling

DED

5 (4)

62.20 ± 8.67

5.80 ± 1.30

3.40 ± 1.14

TF: 11.86 ± 2.10

LF: 11.02 ± 1.04

Control

5 (4)

61.80 ± 7.79

13.80 ± 1.64

8.20 ± 0.84

TF: 9.79 ± 0.84

LF: 10.59 ± 1.90

MRM assay

DED

17 (13)

60.92 ± 9.01

5.76 ± 1.52

3.58 ± 0.87

TF: 13.06 ± 1.81

LF: 11.44 ± 1.19

Control

17 (13)

61.06 ± 7.91

11.47 ± 2.00

7.89 ± 1.26

TF: 11.78 ± 4.90

LF: 11.69 ± 3.69

  1. Data are means ± standard deviation; MRM, Multiple reaction monitoring; DED, dry eye disease; TF, tear fluid; LF, lacrimal fluid.