Table 2 Differentially expressed marker proteins obtained from MRM assay to be consistent with DEPs in LFQ data. (* Fold change > 1.5, p value < 0.05, AUC > 0.7).
From: Proteomic analysis of human lacrimal and tear fluid in dry eye disease
Protein name | Gene Name | Peptide sequence | fold change (DED/CT) | p value (T-test) | AUC | Consistent alteration |
|---|---|---|---|---|---|---|
Lysosomal alpha-glucosidase | GAA | GVFITNETGQPLIGK | 1.75 | 0.00 | 0.88 | Up in TF |
NAD(P)H dehydrogenase [quinone] 1 | NQO1 | ALIVLAHSER | 1.74 | 0.01 | 0.79 | Up in TF |
Transitional endoplasmic reticulum ATPase | VCP | VINQILTEMDGMSTK | 1.55 | 0.01 | 0.78 | Up in TF |
Lactoperoxidase | LPO | IHGFDLAAINTQR | 1.97 | 0.01 | 0.82 | Up in LF |
Phospholipase A2, membrane associated | PLA2G2A | FSNSGSR | 1.92 | 0.00 | 0.88 | Up in LF |
Haptoglobin | HP | VTSIQDWVQK | 1.78 | 0.01 | 0.71 | Up in LF |
Pyruvate kinase PKM | PKM | IYVDDGLISLQVK | 1.66 | 0.00 | 0.80 | Up in LF |
Alpha-1-antitrypsin | SERPINA3 | ADLSGITGAR | 1.61 | 0.01 | 0.74 | Up in LF |
Protein disulfide-isomerase | P4HB | VDATEESDLAQQYGVR | 1.52 | 0.00 | 0.88 | Up in LF |
Carbonyl reductase [NADPH] 1 | CBR1 | IGVTVLSR | 1.51 | 0.00 | 0.71 | Up in LF |
Alpha-1-acid glycoprotein 1 | ORM1 | YVGGQEHFAHLLILR | 1.50 | 0.02 | 0.70 | Up in LF |
Zinc-alpha-2-glycoprotein | AZGP1 | QDPPSVVVTSHQAPGEK | 0.67 | 0.01 | 0.75 | Down in LF |
Lipocalin-1 | LCN1 | VTMLISGR | 0.58 | 0.00 | 0.83 | Down in LF |
Ig kappa chain C region | IGKC | VDNALQSGNSQESVTEQDSK | 0.57 | 0.00 | 0.79 | Down in LF |
Hemoglobin subunit alpha | HBA1 | MFLSFPTTK | 0.57 | 0.02 | 0.78 | Down in LF |
Hemoglobin subunit beta | HBB | EFTPPVQAAYQK | 0.56 | 0.05 | 0.76 | Down in LF |
