Table 1 Top 20 biomarker candidate clusters.

From: A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease

Cluster #

Cluster size (n)

m/z

Chg.

Cluster similarity (p-value)

Subjects (n)

Median change

AUC (C - AD)

AA Sequence

Protein name

AD - C

MCI-AD - C

MCI-S - C

7367

39

794.115

5

0.073

119

215%**

153%**

35%*

0.96*

  

69078

18

664.799

2

0.000

94

18%**

15%**

0%

0.92*

  

32527

11

777.426

3

0.001

68

13%**

8%*

8%

0.92*

  

78065

41

748.382

2

0.001

120

38%**

20%**

9%*

0.91*

aDSGSSEEkQ

osteopontin

4243

10

696.457

5

0.000

59

103%*

67%**

59%**

0.91*

  

82223

22

794.885

2

0.000

111

28%**

22%**

11%**

0.90*

tVASHTSDSDVPSG

clusterin

34935

10

810.044

3

0.001

58

16%**

16%*

-1%

0.9*

  

9084

13

836.597

5

0.000

86

47%**

35%**

27%*

0.87*

  

36033

34

823.45

3

0.006

120

18%**

13%*

3%*

0.87*

kVEQAVETEPEPELRQQ

ApoE

61266

14

1380.71

3

0.000

70

−20%**

−7%

−10%*

0.86*

  

1889

53

427.579

3

0.014

120

15%**

8%*

6%

0.86*

  

33238

10

787.612

3

0.001

69

19%**

34%**

15%*

0.85*

  

25327

14

684.044

3

0.003

60

9%**

9%*

10%*

0.85*

  

13290

25

840.651

4

0.038

111

17%**

16%**

7%

0.85*

gGSLPSEEkGHPQEESEESNVSMASLGE

secretogranin-1

10464

9

786.901

4

0.002

59

22%**

4%

8%

0.85

  

71623

10

685.336

2

0.000

61

13%**

7%*

7%*

0.83*

  

12243

10

911.104

5

0.000

70

−28%**

−7%

6%

0.82

  

87816

44

848.511

2

0.002

69

16%**

24%**

6%

0.8*

  

6405

11

690.794

4

0.000

60

13%*

−2%

−1%

0.79*

  

53204

8

1088.54

3

0.000

60

4%*

16%*

8%

0.79*

  
  1. **Indicates statistical significance (p < 0.001), *Indicates statistical significance (p < 0.05). Top 20 spectral clusters sorted according to descending Area Under ROC curve in AD vs C. Columns (left to right) are: cluster id number; number of spectra included in the cluster; cluster average mass-to-charge ratio (m/z); charge; average p value of cluster similarity as calculated by the MS Cluster algortihm; the number of study subjects in which the cluster was quantified; median relative change in abundance between AD and C, between MCI-AD and C, and between MCI-S and C; area under curve from ROC curve analysis of C vs. AD; amino acid sequence of peptides identified by database searching; protein name.
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