Figure 7

(a) Immunohistochemical difference in PV+ cells in hippocampal, frontal and entorhinal cortical structures of mice injected with the buffer (upper panel images) or K18 (bottom panel images). (b) Quantification of PV+ cell loss in the cortex and enthorinal cortex. Scatter plot shows no major difference in the average number of PV+ cell loss in cortical structures, whilst limited PV cells were detected in the hippocampus. Accurate quantification of PV+ was difficult in 2 animals, which were discarded from the anlaysis. One way ANOVA, Bonferroni correction for multiple comparisons, significance levels p < 0.05, K18 (n = 8) vs buffer (n = 10). Scale bars 250 and 500 µm.