Figure 1 | Scientific Reports

Figure 1

From: Effects of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer

Figure 1

CpG island methylation in precancerous conditions in three different parts of the stomach (antrum, angulus, and corpus). (A) In AM, hypermethylation of CDH1 gene, and MINT1 and MINT31 loci was observed throughout the stomach in the AG and GC groups. CDH1 methylation in AM, a predictive marker for gastric dysplasia, was significantly higher at the greater curvature of corpus in the GC group than in the AG group (p = 0.0002). (B) In IM, DNA hypermethylation of most genes other than CDH1 in the AG group and CDKN2A and MLH1 in the GC group was seen in the various portions of the stomach.

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