Figure 3

Volcano plot of microRNA microarray data of myocardium from obese and normal mice at 16 months. The y-axis values show the negative logarithm base 10 of the P-value. The x-axis is shown as the log 2 differences in estimated relative expression values. The dotted horizontal line on the plot represents the α-level used for this analysis (0.05). Vertical dotted lines represent the threshold for the log 2-fold change (equivalent to a 2-fold change). Thus, the green and red dots correspond to miRNAs that show a significant 4-fold or higher in expression between obese and normal mice (n = 3).