Figure 1 | Scientific Reports

Figure 1

From: Comparative sphingolipidomics of disease-causing trypanosomatids reveal unique lifecycle- and taxonomy-specific lipid chemistries

Figure 1

Distinct phosphosphingolipids (phospho-SPL) found in eukaryotic model organisms and trypanosomatids. (a) Structures of currently known phosphoSP found in human, Saccharomyces cerevisiae, Drosophila melanogaster and the trypanosomatids, Leishmania donovani, T. brucei and T. cruzi. Variations occur at the headgroup (R), long chain base (LCB) and fatty acyl (R1) chain. (b–g) Headgroup separation of SP in various organisms by liquid chromatography and precursor ion scans monitoring major LCB. (b) Chromatographic profile of SP found in human cell line, THP-1. (c) Chromatographic profile of SP found in S. cerevisiae. (d) Chromatographic profile of SP found in D. melanogaster. (e) Chromatographic profile of SP found in the trypanosomatid, L. donovani. (f) Chromatographic profile of SP found in the trypanosomatid, T. brucei. (g) Chromatographic profile of SP found in the trypanosomatid, T. cruzi. Abbreviations: Cer-ceramides, EPC-phosphoethanolamine ceramides, GluCer-glucosylceramides, IPC-inositolphosphoryl ceramides, LacCer-lactosylceramides, SM-sphingomyelins.

Back to article page