Figure 3 | Scientific Reports

Figure 3

From: Calcineurin/P-ERK/Egr-1 Pathway is Involved in Fear Memory Impairment after Isoflurane Exposure in Mice

Figure 3

1 h isoflurane exposure decreased the phosphorylation of ERK stimulated by fear condition. (A) In hippocampus, compared to MT groups, FC groups showed significantly higher level of P-ERK 90 min, 49 h, 7 days post conditioning tone fear memory tests, which were impaired by isoflurane. 7 days after FC training, the inhibited ERK phosphorylation in FC group recovered to the similar level as Air group. (B) In amygdala, similar adverse effect of isoflurane on P-ERK can be seen. All data are presented as mean ± SEM, n = 6 for each group. **P < 0.05 compared with MT group; ***P < 0.001 compared with MT group; ### P < 0.001 compared with Iso group.

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