Table 1 Antibacterial activities of synthetic peptides and and antibiotics.

From: Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus

Peptides

Sequences

M. Wa

MICb/MBCc (μM)

Vv

St

Sa

HPA3P

AKKVFKRLPKLFSKIWNWK-NH2

2417.2

8/8

8/8

16/16

HPA3P2

AKKVFKRLPKLPSKIWNWK-NH2

2367.0

>64/>64

>64/>64

>64/>64

A3-APO

RPDKPRPYLPRPRPPRPVR-NH2

2350

>64/>64

32/32

>64/>64

HPA3PHis

AKKVFKRLPKLFSKIWNWKHHHHHH-NH2

3348.1

8/8

32/32

16/16

HPA3P2His

AKKVFKRLPKLPSKIWNWKHHHHHH-NH2

3280.9

64/64

>64/>64

>64/>64

A3-APOHis

RPDKPRPYLPRPRPPRPVRHHHHHH-NH2

3480.7

>64/>64

32/32

>64/>64

Antibiotics

Classification

M. W a

MIC b /MBC c (μM)

Vv

St

Sa

Ampicillin

Penicillins

349.4

>64/>64

8/8

1/1

Doxycycline

Tetracyclins

444.4

0.5/0.5

8/16

1/2

Erythromycin

Macrolides

733.9

2/4

>64/>64

0.5/1

  1. aM.W: molecular weight.
  2. bMIC: minimal inhibitory concentration against Vibrio vulnificus (Vv), Salmonella typhimurium (St), and Staphylococcus aureus (Sa).
  3. cMBC: minimal bactericidal concentration against Vv, St, and Sa.