Table 5 Biodistribution of radioactivity after i.v. injection of 67Ga-DOTA-(D-Asp)14 in micea.

From: Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone

Tissue

Time after injection

10 min

60 min

180 min

Blood

2.46 (0.60)

0.09 (0.04)

0.03 (0.01)

Liver

0.51 (0.12)

0.15 (0.04)

0.05 (0.03)

Kidney

8.15 (3.86)

1.21 (0.57)

0.54 (0.12)

Small-intestine

0.55 (0.06)

0.18 (0.04)

0.12 (0.02)

Large-intestine

0.40 (0.06)

0.10 (0.01)

0.20 (0.01)

Spleen

0.48 (0.13)

0.12 (0.03)

0.12 (0.04)

Pancreas

0.88 (0.07)

0.27 (0.04)

0.14 (0.06)

Lung

1.75 (0.47)

0.28 (0.09)

0.03 (0.01)

Heart

0.94 (0.16)

0.18 (0.04)

0.11 (0.03)

Stomachb

0.28 (0.08)

0.07 (0.01)

0.06 (0.01)

Bone (Femur)

11.90 (2.99)

13.03 (0.90)

14.78 (2.34)

Muscle

0.77 (0.15)

0.16 (0.03)

0.16 (0.11)

Brain

0.06 (0.01)

0.01 (0.01)

0.01 (0.00)

F/B ratioc

4.90 (0.70)

180.99 (91.94)

526.37 (130.49)

  1. aExpressed as % injected dose. Each value represents the mean (SD) for five animals.
  2. bExpressed as % injected dose.
  3. cFemur:blood ratio.
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