Figure 3 | Scientific Reports

Figure 3

From: Physicochemical characterisation, immunogenicity and protective efficacy of a lead streptococcal vaccine: progress towards Phase I trial

Figure 3

Binding of vaccine antisera to GAS. To assess the binding of vaccine antisera (J8-CRM or MJ8CombiVax) to the surface of various GAS isolates, flow cytometry was performed. The assay measured the binding of vaccine antibody through FITC conjugated secondary IgG. Binding of J8-CRM or MJ8CombiVax antibodies to GAS NS1 (CovR/S WT) and GAS NS88.2 (CovR/S MT) are shown as mean fluorescence intensity (MFI). The antisera from CRM or PBS immunised mice were used as controls. Data for each bar are Mean ± SEM. Significance between the binding efficiency of different vaccine antisera to the same GAS strain was determined using a student t-test. *p < 0.05.

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