Table 4 Impact of the subject misclassification secondary to analytical and biological variation alone on the potential increase in the prevalence of various diagnostic categories.
Potential increase in prevalence caused by misclassified subjects | ||||||
|---|---|---|---|---|---|---|
Original classification | WHO criteria | ADA criteria | ||||
Normal (%) | Impaired (%) | Diabetes (%) | Normal (%) | Impaired (%) | Diabetes (%) | |
Normal fasting plasma glucose | — | 46.8 | 0 | — | 32.5 | 0 |
Impaired fasting plasma glucose | 1.9 | — | 14.4 | 6.6 | — | 14.2 |
Diabetes | 0.01 | 7 | — | 0 | 2.2 | — |
Normal oral glucose tolerance test | — | 36.8 | 0 | — | 36.8 | 0 |
Impaired oral glucose tolerance test | 6.2 | — | 26.6 | 6.2 | — | 26.6 |
Diabetes | 0.01 | 6.8 | — | 0.01 | 6.8 | — |
Normal HbA1c (at CVa = 3.5%) | — | 48 | 1.3 | — | 16.5 | 0 |
Pre-diabetes | 6.4 | — | 31.8 | 25.3 | — | 33.1 |
Diabetes | 0.03 | 4.4 | — | 0 | 1.6 | — |
Normal HbA1c (at CVa = 2.0%) | — | 30.5 | 0 | — | 11.6 | 0 |
Pre-diabetes | 5.2 | — | 17.9 | 19.5 | — | 18.2 |
Diabetes | 0 | 3.6 | — | 0 | 1.2 | — |
