Figure 2
From: Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells
Cytoskeleton-associated proteins interact with cyclin D1 in JeKo1 cells. The 200 proteins with the highest peptide coverage (Table S4) were analysed by DAVID Bioinformatics Resources v6.7 (ref.16). Relevant proteins were uploaded using their UniProt ID and organised into functional groups by the tool, according to GO terms. Among them, 51 were cytoskeleton-associated proteins (enrichment score: 13.16, p-value: 4.7 × 10−14). (A) The same 200 proteins were next clustered with the PANTHER™ classification system v12.0 according to their associated biological processes, molecular functions and protein classes (www.pantherdb.org, ref.19). Results are presented as pie charts, with the percentage of proteins for some of the more relevant fractions. (B) The network designed with STRING (v10.5, www.string-db.org, ref.20) summarises associations between the 51 proteins previously characterised and cyclin D1. This analysis predicted functional enrichment in actin-filament-based processes (pathway ID: GO 0030029), with a false discovery rate of 7.69 × 10−11.
