Figure 5

(A) Schematic representation of the bend angle (θ) of helix VI of P2Y₁R. (B) Plots of θ in the 300-ns aMD trajectories of the 2MeSADP-P2Y₁R, apo-P2Y₁R and MRS2500-P2Y₁R systems. Snapshots of helix VI extracted from the aMD trajectories of (C) the 2MeSADP-P2Y₁R system, (D) the apo-P2Y₁R system and (E) the MRS2500-P2Y₁R system. The initial structures of helices VI and III are colored in red. The helix VI structures are superimposed on the initial structure with the C_α atoms of residues Leu254^6.29 to Leu288^6.63.