Figure 4 | Scientific Reports

Figure 4

From: 11β-hydroxysteroid dehydrogenase type 1 has no effect on survival during experimental malaria but affects parasitemia in a parasite strain-specific manner

Figure 4

11β-HSD1 does not change plasma glucose, ALT or AST levels and does not affect lung pathology upon infection with PcAS. Hsd11b1 Del/Del and WT mice were infected with PcAS. At the peak of infection, 10 days post-infection, plasma glucose levels, alanine aminotransferase (ALT) and aspartate transaminase (AST) levels were measured. Also, the weight of the left lung and the protein content in the bronchoalveolar lavage fluid (BALF) were determined. Each dot represents the result from an individual mouse. Horizontal lines in between data points represent group medians and analysis was by Mann-Whitney U-test. Asterisks above individual data sets indicate statistical differences compared to the uninfected control group. Data from 2 separate experiments. n = 16 (8 F and 8 M) for WT and n = 15 (8 F and 7 M) for Hsd11b1 Del/Del. ns, not significant.

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