Figure 5

Effect of 11β-HSD1 on the disease and parasitemia course in PbNK65 1556Cl1-infected mice. Hsd11b1 ^Del/Del and WT mice were infected with Plasmodium berghei NK65 (PbNK65) clone 1556Cl1 and a differentiation was made between hyperparasitemic (HP) and non-hyperparasitemic (non-HP) mice. For the clinical score and body weight of non-HP mice, see supplementary Fig. S1. Survival (a,b), individual peripheral parasitemia (c,d), clinical score (e,f) and body weight (g,h) of the mice is shown. Survival was analysed by Log-rank test. Data are means ± SEM and were analysed by Mann-Whitney U-test. Asterisks on top indicate a difference between the infected Hsd11b1 ^Del/Del and WT mice. Data from 2 separate experiments. n = 16 (7 F and 9 M) for WT and n = 18 (9 F and 9 M) for Hsd11b1 ^Del/Del. n = 9 (3 F and 6 M) for HP WT and n = 5 (2 F and 3 M) for HP Hsd11b1 ^Del/Del.