Figure 7
From: Margination and stretching of von Willebrand factor in the blood stream enable adhesion
VWF adhesion in experiments. (a) VWF adhesion is monitored over time and represented by the intensity and area of adhered VWF spots at the channel bottom, as shown by the two successive images of the experiment for H t = 0.5 at \({\dot{\gamma }}_{{\rm{w}}}=500\) s −1. The isotropic background level of intensity, which characterizes VWF margination, is subtracted. (b) Potential-adhesion probability Ψ estimated from simulations as a function of H t and \({\dot{\gamma }}_{{\rm{w}}}^{\ast }\) for N = 26 (L VWF = 15 μm). It characterizes the probability of adhesion which is related to the slope of VWF-adhesion curves in experiments at short times before the adhesion saturation has been reached. (c) Adhesion of VWF to collagen in microfluidic channels for various wall shearrates and hematocrits (H t = 0.1, H t = 0.3, H t = 0.5). VWF adhesion is monitored over time. The error bars in the plots show the deviation of monitored data from four independent experiments.
