Figure 4
Combination therapy with anti-PD-1 and anti-CD4 mAb significantly prolong NXS2-tumor-free progression in mice. (a) Kaplan-Meier analysis of A/J mice challenged i.v. with a tumorigenic dose of NXS2-luc cells on day 0 and then treated with anti-PD-1 and anti-CD4 mAb shows a significant increase in mice survival, with 2/6 mice cured from disseminated tumors. P values of combined treatments vs irrelevant Ab controls are indicated (Wilcoxon log-rank test). The experiment shown is representative of two independent ones with identical results. (b) The combined treatment with anti-PD-1 and anti-CD4 mAb potently inhibits Neuroblastoma progression even if started at a later time point (+6 days from challenge). P values of delayed combined treatments vs irrelevant Ab controls are indicated (Wilcoxon log-rank test). Percentages of progression-free mice are indicated on the Y-axis and the fraction of progression-free mice of each group is given in brackets.
