Figure 7
From: Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma
Transgenic overexpression of Norrin enhances Wnt/β-catenin signaling in the trabecular meshwork. (A) Immunostaining for β-catenin (green) in the anterior eye segment of two-month-old mice. In DBA/2J mice a marked signal for β-catenin is observed in the epithelium of the ciliary body (CB), whereas immunoreactivity in the trabecular meshwork (TM) is weak. In contrast, in the TM of DBA/2J/Pax6-Norrin mice intense staining for β-catenin is detected. Ir, iris; Co, cornea; blue, DAPI staining; scale bars: 20 µm. (B) In DBA/2J/Pax6-Norrin and their DBA/2J littermates IBA1 positive cells (red) are present in ciliary body (CB), iris (Ir) and trabecular meshwork (TM). Both strains show no differences in the distribution or number of IBA1 positive cells. Co, cornea; blue, DAPI staining; scale bars: 20 µm.
