Figure 1
From: Krüpple-like-factor 4 Attenuates Lung Fibrosis via Inhibiting Epithelial-mesenchymal Transition
KLF4 expression was downregulated in human IPF lung tissues and mouse models of bleomycin-induced pulmonary fibrosis. Representative microphotographs of immunohistochemistry staining of KLF4 in cancer adjacent normal lung tissue (A, left column) and fibrotic tissues (A, right column) of IPF patients, and mouse models of bleomycin-induced pulmonary fibrosis (B, right column) or control saline group (B, left column). KLF4 expression level in sections of IPF patients or control group (C), and bleomycin-induced fibrosis model or control group (D) were shown by immunoreactive system (IRS) and analyzed.Scale bar was as indicated in the figure. qPCR and western blotting were performed to evaluate the expression of KLF4 in mouse lung tissues of bleomycin-induced pulmonary fibrosis and control group (E,F). The values were expressed as mean ± SD. N = 4 for each group. ***P < 0.001 by t-test.
