Figure 7
Pulmonary function in bleomycin-induced pulmonary fibrosis was improved by treatment with ER stress and PI3K inhibitors. (A,B) Barometric plethysmography was conducted in mice before or 14 days after intratracheal administration of bleomycin (2 U/kg) or saline (vehicle), treated with or without (A) 4-PBA or TUDCA (500 mg/kg, i.p.), or (B) PI3K inhibitor, LY294002 (LY, 50 mg/kg, i.p.) before (prevention) or 7 days (treatment) after bleomycin intratracheal instillation. (C) Barometric plethysmography was conducted in mice before or indicated time periods after intratracheal administration of bpV (2.5 mm).
