Table 2 Comparison of target and OARs’ dose-volume parameters in three radiation techniques.

From: Dosimetric comparison of the helical tomotherapy, volumetric-modulated arc therapy and fixed-field intensity-modulated radiotherapy for stage IIB-IIIB non-small cell lung cancer

  

TOMO

VMAT

IMRT

P value

T vs. V

T vs. I

V vs. I

PTV

CI

0.76 ± 0.06

0.81 ± 0.07

0.75 ± 0.06

0.013

0.290

0.001

HI

0.14 ± 0.04

0.10 ± 0.03

0.11 ± 0.02

0.002

0.003

0.070

Dmean(Gy)

63.37 ± 1.08

62.41 ± 0.61

62.68 ± 0.66

0.000

0.002

0.047

Dmax (Gy)

66.39 ± 1.29

65.40 ± 1.02

65.66 ± 0.93

0.007

0.011

0.203

D1 (Gy)

65.61 ± 1.29

64.67 ± 0.90

64.95 ± 0.81

0.005

0.019

0.134

D2 (Gy)

65.43 ± 1.27

64.23 ± 1.65

64.79 ± 0.79

0.006

0.023

0.103

D50 (Gy)

63.77 ± 1.18

62.60 ± 0.71

62.86 ± 0.54

0.000

0.000

0.062

D95 (Gy)

59.82 ± 0.48

59.94 ± 0.25

59.91 ± 0.23

0.267

0.421

0.616

D98 (Gy)

57.16 ± 1.99

58.41 ± 0.71

58.24 ± 0.61

0.004

0.011

0.265

D99 (Gy)

54.94 ± 3.47

57.05 ± 1.20

56.65 ± 1.16

0.004

0.019

0.163

V95 (%)

98.32 ± 0.89

99.03 ± 0.57

98.88 ± 0.49

0.001

0.006

0.224

V100 (%)

94.63 ± 0.76

94.83 ± 0.65

94.73 ± 0.69

0.252

0.674

0.522

V105 (%)

63.22 ± 19.24

35.05 ± 22.15

43.15 ± 16.45

0.000

0.000

0.054

Total lung

MLD (Gy)

12.64 ± 3.75

12.39 ± 3.07

12.50 ± 3.18

0.834

0.969

0.868

V5 (%)

44.44 ± 12.20

43.43 ± 12.62

42.25 ± 11.11

0.898

0.295

0.615

V10 (%)

32.72 ± 10.08

31.47 ± 8.59

32.86 ± 8.71

0.662

0.519

0.438

V20 (%)

21.80 ± 7.47

22.21 ± 6.01

24.24 ± 6.20

0.762

0.019

0.141

V30 (%)

15.14 ± 5.88

15.74 ± 4.35

16.71 ± 4.07

0.677

0.029

0.324

V40 (%)

10.60 ± 4.75

11.03 ± 3.43

11.32 ± 3.82

0.747

0.157

0.756

V50 (%)

7.07 ± 3.67

7.25 ± 2.76

7.29 ± 3.15

0.872

0.767

0.959

Heart

MHD (Gy)

14.22 ± 8.73

11.69 ± 7.41

11.23 ± 7.06

0.228

0.033

0.882

V5 (%)

51.99 ± 27.95

41.41 ± 25.97

38.91 ± 24.81

0.278

0.002

0.684

V10 (%)

40.00 ± 25.66

30.31 ± 22.11

29.76 ± 20.13

0.231

0.013

0.913

V20 (%)

28.21 ± 21.35

21.80 ± 16.92

21.32 ± 16.17

0.198

0.043

0.792

V30 (%)

19.11 ± 15.17

14.02 ± 11.33

14.61 ± 11.35

0.234

0.067

0.801

V40 (%)

11.25 ± 9.14

9.07 ± 7.89

9.13 ± 7.29

0.485

0.189

0.969

V50 (%)

5.75 ± 5.18

5.19 ± 5.48

4.97 ± 4.50

0.922

0.641

0.842

Spinal cord

Dmax (Gy)

37.10 ± 10.75

34.82 ± 10.02

37.03 ± 8.84

0.447

0.785

0.352

Esophagus

Dmax (Gy)

65.37 ± 1.22

60.04 ± 13.31

60.48 ± 11.81

0.351

0.324

0.866

Mean (Gy)

33.47 ± 2.06

31.98 ± 1.47

32.26 ± 1.68

0.411

0.512

0.776

  1. Abbreviation: OAR = organs at risk; PTV = planning target volume; CI = conformity index; HI = heterogeneity index; T = helical tomotherapy; V = volumetric-modulated arc therapy; I = intensity-modulated radiotherapy; MLD = mean lung dose; MHD = mean heart dose.
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