Table 2 Maximal relaxation responses (%) and −logEC₅₀ in isolated aorta arteries of 8 month-old variously treated spontaneously diabetic Goto-Kakizaki (GK) rats and age-matched non-diabetic Wistar rats.

  pEC₅₀

7.59 ± 0.1

6.47 ± 0.18^***

7.8 ± 0.24^ϕϕϕ

7.64 ± 0.13^ϕϕϕ

7.4 ± 0.18^ϕϕ

  Maximal relaxation (%)

86.5 ± 3.8

50.7 ± 3.7^***

63 ± 3.6^***,ϕϕϕ

63.1 ± 2.7^***,ϕϕϕ

74.3 ± 3.1 ^{**,ϕϕϕ,§,#}

  pEC₅₀

7.7 ± 0.03

7.6 ± 0.03

7.96 ± 0.05 ^***,ϕϕϕ

7.98 ± 0.04^*,ϕϕϕ

7.9 ± 0.04^*,ϕϕϕ

  Maximal relaxation (%)

97.1 ± 1.2

92.9 ± 1.4

98.1 ± 1.6

98.8 ± 1.4

97.5 ± 2.2