Table 1 Representative circRNA host genes in the pathway analysis.

From: Heterogeneous circRNA expression profiles and regulatory functions among HEK293T single cells

Pathway

circRNA host genes

Lysine degradation**

HADH, ASH1L, SETD2, WHSC1, NSD1, WHSC1L1, EHMT1

Ubiquitin mediated proteolysis**

HUWE1, SMURF1, TRIM37, UBE4B, UBE2G1, CUL5, BIRC6, UBE2I, UBR5, MID1

ErbB signaling pathway**

PIK3CB, PTK2, CRKL, PIK3R3, BRAF, ABL2, MTOR

Protein processing in endoplasmic reticulum**

PDIA6, SEC31B, UBE4B, UBQLN1, UBE2G1, SEC62, NPLOC4, AMFR, MAN1A2

Insulin signaling pathway**

PIK3CB, CRKL, PIK3R3, BRAF, ACACB, ACACA, PRKAG2, MTOR

RNA transport*

NUP214, RANGAP1, KPNB1, CASC3, UBE2I, EIF4G3, NUP205, NDC1

Amoebiasis*

PIK3CB, PTK2, PLCB1, PIK3R3, ADCY1, RAB7A

Selenocompound metabolism*

MTR, PAPSS1, MARS

Bacterial invasion of epithelial cells*

PIK3CB, PTK2, CRKL, PIK3R3, CD2AP

AMPK signaling pathway*

PIK3CB, PIK3R3, ACACA, PRKAG2, PPARG, MTOR

  1. Note: Genes harboring circRNAs were observed to be involved in ten pathways by p-value cutoff at 0.05. (*p < 0.05, **p < 0.01).
Back to article page