Figure 3
From: Efficacy of an Adenoviral Vectored Multivalent Centralized Influenza Vaccine
Hemagglutination Inhibition Assays after Multivalent HA Vaccination. Mice were immunized and boosted with a multivalent mixture of Ad4 and Ad5 expressing the H1, H2, H3 and H5 consensus HA genes at various doses. Sera from the vaccinated mice were assayed for HI antibody titers against a wide panel of divergent influenza strains. The HI titers induced by the lowest dose of vaccine, 1 × 107 vp/mouse are shown (A). A low dose vaccine of 5 × 107 vp/mouse is shown (B). A high dose vaccine of 1 × 1010 vp/mouse is shown (C). The dotted line represents a theoretical titer indicative of protection.
