Figure 4 | Scientific Reports

Figure 4

From: Decoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling

Figure 4

Inhibited nuclear translocation of β-catenin and Smad 2/3 by sLRP6E1E2-expressing Ad. Upon Wnt3a (100 ng/mL) stimulation, the expression of β-catenin and Smad 2/3 was reduced at the cytosols, but increased in the nucleus. In contrast, transduction with dEl-k35/sLRP6E1E2 (50 MOI) decreased nuclear translocation of (a) β-catenin and (b) Smad 2/3. The data are representatives of three independent experiments.

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