Table 2 Volume differences between newborns with congenital heart disease and healthy controls.

From: Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery

Region

Volume (ml), mean (SD)

ANCOVA

 

CHD, n = 30

Control, n = 30

p value

Whole brain

308 (29.3)

335 (33.9)

<0.001

*

Cortical grey matter

122 (14.4)

132 (17.4)

0.003

*

Frontal grey matter

41 (5.0)

44 (5.6)

0.011

*

Parietal grey matter

28 (3.2)

31 (4.5)

0.002

*

Temporal grey matter

25 (3.3)

28 (3.9)

<0.001

*

Occipital grey matter

19 (2.7)

21 (2.8)

0.014

*

Cerebellum

20 (2.3)

22 (2.5)

0.073

Ns

Extra-axial CSF space

78 (20.8)

68 (10.8)

0.011

*

  1. Comparison of groups performed with multivariate general linear models, with PMA included as a covariate. Exploratory regional analyses displayed with *significance and Ns = not significant. Significance did not change with the addition of weight at scan as a covariate.
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