Figure 5 | Scientific Reports

Figure 5

From: Metoprolol prevents chronic obstructive sleep apnea-induced atrial fibrillation by inhibiting structural, sympathetic nervous and metabolic remodeling of the atria

Figure 5

Expression of proteins involved in the Sirt1/AMPK pathway in atria of OSA dogs and metoprolol-treated dogs. (A) Representative bands showing the protein expression of p-Sirt1 and Sirt1 in right atria. (B,C) Statistical results for the expression of p-Sirt1 and Sirt1 in atrial tissue. (D) Representative bands showing the protein expression of p-AMPK and AMPK in right atria. (E,F) Statistical results for the expression of p-AMPK and AMPK in atrial tissue. (G) Representative bands for the protein expression of GLUT4 and FAT/CD36 in right atria. (H,I) Statistical results for the expression of GLUT4 and FAT/CD36 in atrial tissue. The expression levels of these proteins were normalized to the level of GAPDH. **p < 0.01, ***p < 0.001 vs Sham group, # p < 0.05, ## p < 0.01, ### p < 0.001 vs OSA group, n = 6 per group.

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