Figure 3 | Scientific Reports

Figure 3

From: Monocytes from patients with Primary Ciliary Dyskinesia show enhanced inflammatory properties and produce higher levels of pro-inflammatory cytokines

Figure 3

Circulating monocytes of PCD patients show reduced CD15 upregulation upon fMLP stimulation. The expression levels of the selectin ligand CD15 and the selectin CD62L on monocytes of PCD patients (PCD), age-matched healthy pediatric controls (Ped CO) and healthy adult controls (Ad CO) were measured by flow cytometry, either in (a) buffer (untreated) or upon (b) 10−8 M fMLP or (c) 300 ng/ml CCL2 stimulation. The expression levels were normalized to the expression level of the reference Ad CO (%). The expression levels in b and c were normalized to the expression levels in buffer conditions. ‘$’Indicate significant differences in expression levels of the adhesion molecule on the monocytes in response to fMLP or CCL2 stimulation compared to buffer treatment. ‘*’Indicate differences between the PCD patients and a control group (**p < 0.01; Mann Whitney U-test).

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