Figure 4 | Scientific Reports

Figure 4

From: In vivo characterization of the electrophysiological and astrocytic responses to a silicon neuroprobe implanted in the mouse neocortex

Figure 4

No degradation in signal quality for up to 10 weeks after implantation. (a) Example recordings from the probe in M3 from 1 recording site for 10 consecutive weeks. Multi-unit activity was observed for each week. (b) Extracellular recording from a channel with multiunit activity and (c) corresponding logarithmic histogram with estimates of signal (red) and noise (blue). (d) Normalized signal amplitude for 6 mice over 10 weeks. The amplitude was normalized by the median amplitude from week 2 to week 10. Note how the signal amplitude remains stable over time. (e) Extracellular recording from channel without multiunit activity and (f) corresponding logarithmic histogram. The standard deviation of the normal distribution was calculated as an approximation for the noise. (g) Normalized noise amplitude for 6 mice over 10 weeks. The amplitude was normalized by the median amplitude from week 2 to week 10. Note how the noise amplitude remains stable over time.

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