Table 4 Allele and genotype frequencies of five SNPs in SLE patients and health controls.
SNPs | Group | Phase Ia | Phase IIa | Meta-analysis | heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|---|
OR(95% CI) | P | OR(95% CI) | P | OR(95% CI) | P | Model | I 2 (%) | P | ||
rs10515177 | Genotype | |||||||||
GG vs. AA | 0.818(0.279–2.399) | 0.714 | 1.478(0.584–3.744) | 0.410 | 1.169(0.590–2.323) | 0.654 | F | 0.0 | 0.398 | |
GA vs. AA | 0.772(0.584–1.021) | 0.069 | 0.928(0.628–1.370) | 0.706 | 0.836(0.670–1.043) | 0.113 | F | 0.0 | 0.393 | |
Allele | ||||||||||
G vs. A | 0.802(0.626–1.027) | 0.080 | 1.069(0.776–1.474) | 0.683 | 0.893(0.734–1.086) | 0.256 | F | 48.5 | 0.163 | |
Dominant model | ||||||||||
GG + GA vs. AA | 0.774(0.590–1.017) | 0.066 | 0.987(0.684–1.424) | 0.945 | 0.859(0.694–1.063) | 0.163 | F | 24.4 | 0.250 | |
Recessive model | ||||||||||
GG vs. GA + AA | 0.852(0.291–2.496) | 0.770 | 1.496(0.592–3.781) | 0.394 | 1.193(0.604–2.360) | 0.611 | F | 0.0 | 0.422 | |
rs2070107 | Genotype | |||||||||
CC vs. GG | 2.111(1.097–4.062) | 0.025 | 0.646(0.277–1.506) | 0.312 | 1.314(0.376–4.588) | 0.669 | R | 82.1 | 0.018 | |
CG vs. GG | 0.959(0.765–1.203) | 0.719 | 0.620(0.448–0.858) | 0.004 | 0.817(0.536–1.245) | 0.347 | R | 79.2 | 0.028 | |
Allele | ||||||||||
C vs. G | 1.156(0.960–1.393) | 0.127 | 0.702(0.538–0.916) | 0.009 | 0.909(0.558–1.482) | 0.703 | R | 89.0 | 0.003 | |
Dominant model | ||||||||||
CC + CG vs. GG | 1.031(0.828–1.283) | 0.787 | 0.623(0.456–0.852) | 0.003 | 0.849(0.516–1.396) | 0.519 | R | 86.0 | 0.007 | |
Recessive model | ||||||||||
CC vs. CG + GG | 2.137(1.114–4.098) | 0.022 | 0.741(0.319–1.719) | 0.485 | 1.402(0.454–4.333) | 0.557 | R | 78.2 | 0.032 | |
rs2632516 | Genotype | |||||||||
GG vs. CC | 0.812(0.614–1.072) | 0.141 | 1.189(0.786–1.797) | 0.413 | 0.968(0.650–1.442) | 0.872 | R | 63.2 | 0.099 | |
GC vs. CC | 0.835(0.652–1.070) | 0.155 | 1.132(0.781–1.641) | 0.513 | 0.927(0.758–1.134) | 0.460 | F | 46.1 | 0.173 | |
Allele | ||||||||||
G vs. C | 0.904(0.789–1.035) | 0.143 | 1.101(0.902–1.344) | 0.345 | 0.983(0.812–1.191) | 0.864 | R | 61.2 | 0.108 | |
Dominant model | ||||||||||
GG + GC vs. CC | 0.827(0.654–1.045) | 0.111 | 1.152(0.811–1.637) | 0.430 | 0.963(0.692–1.341) | 0.823 | R | 61.9 | 0.105 | |
Recessive model | ||||||||||
GG vs. GC + CC | 0.919(0.738–1.144) | 0.449 | 1.089(0.791–1.500) | 0.601 | 0.971(0.814–1.159) | 0.747 | F | 5.3 | 0.304 | |
rs2877877 | Genotype | |||||||||
GG vs. AA | 1.197(0.817–1.754) | 0.355 | 0.502(0.301–0.836) | 0.008 | 0.822(0.337–2.004) | 0.666 | R | 87.8 | 0.004 | |
GA vs. AA | 0.905(0.737–1.112) | 0.343 | 0.615(0.452–0.836) | 0.002 | 0.787(0.529–1.172) | 0.239 | R | 79.5 | 0.027 | |
Allele | ||||||||||
G vs. A | 1.044(0.898–1.213) | 0.579 | 0.675(0.543–0.840) | <0.001 | 0.846(0.552–1.296) | 0.441 | R | 90.3 | 0.001 | |
Dominant model | ||||||||||
GG + GA vs. AA | 0.946(0.777–1.152) | 0.580 | 0.591(0.442–0.790) | <0.001 | 0.786(0.485–1.274) | 0.328 | R | 87.4 | 0.005 | |
Recessive model | ||||||||||
GG vs. GA + AA | 1.252(0.864–1.813) | 0.234 | 0.624(0.382–1.020) | 0.060 | 0.923(0.453–1.881) | 0.826 | R | 82.2 | 0.018 | |
rs2067079 | Genotype | |||||||||
TT vs. CC | 0.906(0.662–1.241) | 0.538 | 0.397(0.235–0.672) | 0.001 | 0.611(0.282–1.323) | 0.212 | R | 84.9 | 0.010 | |
TC vs. CC | 1.142(0.927–1.408) | 0.213 | 0.412(0.300–0.565) | <0.001 | 0.720(0.269–1.933) | 0.515 | R | 96.5 | <0.001 | |
Allele | ||||||||||
T vs. C | 1.005(0.872–1.159) | 0.945 | 0.618(0.503–0.760) | <0.001 | 0.793(0.493–1.276) | 0.339 | R | 93.1 | <0.001 | |
Dominant model | ||||||||||
TT + TC vs. CC | 1.085(0.891–1.322) | 0.416 | 0.409(0.301–0.557) | <0.001 | 0.693(0.273–1.764) | 0.442 | R | 96.3 | <0.001 | |
Recessive model | ||||||||||
TT vs. TC + CC | 0.847(0.630–1.140) | 0.274 | 0.690(0.425–1.119) | 0.133 | 0.770(0.601–0.987) | 0.039 | F | 0.0 | 0.512 | |
