Figure 3 | Scientific Reports

Figure 3

From: Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome

Figure 3

The fluorescent signal from viral particles is robust and remains visible in a cranial window more than 10 minutes after intravenous delivery to the tail vein of an anesthetized mouse. (A) A transparent cranial window at the parieto-occipital cortex of an adult mouse permits visualization of the pial vasculature; scale bar, 750 µm; (B) A bolus of AAV9-138-maleimide 660-C2 labelled viral particles remains visible in the cranial window after a tail vein injection unlike the dye control which washes out and the AAV9 control which has minimal fluorescence; scale bar, 375 µm; (C) The labelled AAV9-138 shows a much higher peak than the dye control or the control AAV9.

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